![]() ![]() A complex interplay of environmental, genetic, nutritional, physiological and behavioural factors plays a role in these processes. It is well established that changes in bone metabolism during the developmental stages of growth, modelling and remodelling determine long-lasting physiological parameters, such as final height achieved, peak bone mass, bone quality and bone health. ![]() The human skeleton is composed of bone, a living tissue that undergoes constant development throughout life. © This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Karolinska University Hospital, Stockholm, SwedenĬorresponding-Author Signe Sparre Beck-NielsenĬentre for Rare Diseases, Skejby, Aarhus University Hospital, Aarhus, Denmark and Department of Clinical Medicine, Aarhus University, Aarhus, PalleJuul-Jensens Boulevard 99, DK-8200, Aarhus, Denmark, Tel: +45-5172-9247, E-mail: April 2021 Italian National Paediatric Coordinator Endo-ERN (SIEDP), EU-Endo-ERN Advisory Board Member, Italy REVIEW Article 4 1 OPEN ACCESS 10.23937/2643-4571/1710029ĭefining a Growing and Maturing Skeleton and its Relevance in Diseases that Affect Skeletal Growth, Such as X-Linked Hypophosphataemia (XLH)Ĭentre for Rare Diseases, Skejby, Aarhus University Hospital, Aarhus, Denmark and, Department of Clinical Medicine, Aarhus University, Denmark
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